Should β-blockers be used in septic shock?

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Should β-blockers be used in septic shock?

Methods Objective: The objective of the study was to investigate the effect of the short-acting β-blocker esmolol in patients with severe septic shock. Design: An open-label, randomized phase 2 study was conducted between November 2010 and July 2012. Setting: The study was conducted in a university hospital ICU. Subjects: Patients were in septic shock with a heart rate of 95/minute or higher re...

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Early goal-directed therapy should be used in septic shock.

Crit Care Resuscitation ISSN: 1441-2772 4 September 2006 8 3 246-246 © C r i t C a r e R es u s c i t a t i on 20 06 www.jficm.anzca.edu.au/aaccm/journal/publications.htm Points of view this process, and this is supported both b clinical experience and by scientific evidence. The cardiovascular abnormalities associated progression are well known to all intensivists. lar volume depletion, vasodi...

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β-blockers in septic shock: are we there yet?

Septic shock is characterized by circulatory collapse and diminished tissue perfusion, leading to organ dysfunction in the setting of systemic infection. The mechanisms of septic shock are incompletely understood; moreover, its incidence is increasing, and its mortality remains unacceptably high. In addition to antimicrobial and supportive treatments, no other therapy has a survival benefit, de...

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Pro/con debate: Should synthetic colloids be used in patients with septic shock?

You have recently heard reports that synthetic colloids may be associated with renal failure and other morbidities in certain populations of critically ill patients. You have been asked by the hospital chief of staff whether there should be a suspension of the use of synthetic colloids until further information is available. You need to make a decision.

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The International Sepsis Forum's controversies in sepsis: corticosteroids should be used to treat septic shock

The use of corticosteroids in septic shock remains controversial. It has been demonstrated that high doses of steroids (30 mg/kg methylprednisolone) for short periods of time are not beneficial. More recent studies using smaller doses (200-300 mg/day hydrocortisone) for longer periods of time have shown beneficial effects. These positive effects have included reversal of shock, trends toward de...

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ژورنال

عنوان ژورنال: Critical Care

سال: 2014

ISSN: 1364-8535

DOI: 10.1186/cc13878